Bromethalin—a Promising New Rodenticide
نویسندگان
چکیده
Bromethalin is a unique highly potent rodenticide exhibiting a mode of action different from anticoagulant rodenticides. Bromethalin provides a lethal dose to rodents in a single feeding with death generally delayed two to three days. Rodents do not discriminate against bromethalin bait; therefore, excellent bait acceptance is achieved with no prebaiting. Field studies have shown bromethalin bait to be highly efficacious against Norway rats and house mice under a variety of field conditions. Laboratory and field trial data indicate bromethalin is effective against known anticoagulant–resistant rodent populations. Toxicological data indicate bromethalin bait is relatively safe to nontarget species as well as to the environment. INTRODUCTION The discovery of resistance in rats to anticoagulant rodenticides (Boyle 1960, Jackson and Kaukeinen 1972) stimulated investigators at Lilly Research Laboratories to search for a replacement rodenticide with a unique mode of action different from anticoagulants. This research led to the discovery of the toxic nature of certain classes of diphenylamines (Dreikorn 1978) and, through the development of a structure-activity relationship, to the subsequent discovery of bromethalin (Dreikorn 1980, Dreikorn et. al. 1979). Bromethalin is a unique, highly potent, single –feeding rodenticide. While providing a lethal dose at the initial feeding, death is often delayed two to three days, but further feeding is inhibited. Documentation for the registration of bromethalin in the U.S. has been submitted to the EPA. PHYSICAL CHARACTERISTICS Technical bromethalin is a pale yellow, odorless, crystalline solid. Bromethalin is soluble in many organic solvents but essentially insoluble in water (<10 parts per billion). Technical bromethalin is stable under ordinary storage conditions.
منابع مشابه
Fatal bromethalin poisoning.
Bromethalin is a neurotoxin found in some rodenticides. A delusional 21-year-old male presented to a hospital with altered mental status the day after ingesting a bromethalin-based rodenticide. He died 7 days after his self-reported exposure to c. 17 mg bromethalin (equivalent to 0.33 mg bromethalin/kg). His clinicopathologic course was characterized by altered mental status, obtundation, incre...
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تاریخ انتشار 2017